01236nas a2200169   4500008004100000245008500041210006900126260001500195520069200210100002200902700001800924700001900942700001600961700002100977700002600998856004201024       2001                        eng d00aIntegration of Computational Techniques for the Modelling of Signal Transduction0 aIntegration of Computational Techniques for the Modelling of Sig  bWSES Press3 aA cell can be seen as an adaptive autonomous agent or as a society of adaptive autonomous agents, where each can exhibit a particular behaviour depending on its cognitive capabilities. We present an intracellular signalling model obtained by integrating several computational techniques into an agent-based paradigm. Cellulat, the model, takes into account two essential aspects of the intracellular signalling networks: cognitive capacities and a spatial organization. Exemplifying the functionality of the system by modelling the EGFR signalling pathway, we discuss the methodology as well as the purposes of an intracellular signalling virtual laboratory, presently under development.1 aGonzález, P., P.1 aCárdenas, M.1 aGershenson, C.1 aLagunez, J.1 aMastorakis, N.E.1 aPecorelli-Peres, L.A.  uhttp://uk.arxiv.org/abs/cs.MA/021103001136nas a2200145   4500008004100000245011000041210006900151260002500220520062800245100002200873700001900895700001800914700001600932856004200948       2000                        eng d00aModelling Intracellular Signalling Networks Using Behaviour-Based Systems and the Blackboard Architecture0 aModelling Intracellular Signalling Networks Using BehaviourBased  aMontego Bay, Jamaica3 aThis paper proposes to model the intracellular signalling networks using a fusion of behaviour-based systems and the blackboard architecture. In virtue of this fusion, the model developed by us, which has been named Cellulat, allows to take account two essential aspects of the intracellular signalling networks: (1) the cognitive capabilities of certain types of networks' components and (2) the high level of spatial organization of these networks. A simple example of modelling of Ca2+ signalling pathways using Cellulat is presented here. An intracellular signalling virtual laboratory is being developed from Cellulat.1 aGonzález, P., P.1 aGershenson, C.1 aCárdenas, M.1 aLagunez, J.  uhttp://uk.arxiv.org/abs/cs.MA/0211029