Gene Transcription: Two Worlds Merged

Complexity Digest 2008.18 - 13

1-May -2008

PDF files of our annual editions are available at www.comdig.de/AnnualEditions.html

Aletter from Gottfried Mayer to our readers and friends is at http://www.comdig.de/GMLetter.html

Gene Transcription: Two Worlds Merged, Nature

Excerpts: Why would two distant genes - on separate chromosomes and from different nuclear locations - unite in response to signals for gene expression? They might be seeds for the formation of transcriptional hubs.

Gene transcription occurs largely at the submicroscopic scale. So although microscopic analysis of nuclear architecture has implicated various structures in this process, it has lacked the power to unravel the role that higher-order organization of chromatin (complexes of DNA and histone proteins) has in the expression of individual genes.

Source: Gene Transcription: Two Worlds Merged
[ http://www.nature.com/nature/journal/v452/n7190/full/452946a.html ], David M. Lonard, Bert W. O'Malley, DOI: 10.1038/452946a, Nature 452, 946-947, 08/04/24