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28-Jul-2003

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The Segmentation Clock: Converting Embryonic Time into Spatial Pattern, Science
 









Excerpts: In most animal species, the anteroposterior body axis is generated by
the formation of repeated structures called segments. In vertebrate
segmentation, a specialized mesodermal structure called the somite gives rise to
skeletal muscles, vertebrae, and some dermis. Formation of the somites is a
rhythmic process that involves an oscillator -the segmentation clock- (...).
This process converts the temporal oscillations into the periodic spatial
pattern of somite boundaries. The study of somite development provides insights
into the spatiotemporal integration of signaling systems in the vertebrate
embryo.
Source: The Segmentation Clock: Converting Embryonic Time into Spatial Pattern[
http://www.sciencemag.org/cgi/content/full/301/5631/328 ], Olivier Pourquie,
Science, 328-330, Jul 18 2003

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