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28-May-2001

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Researchers Shed Light On		Gambling And The Brain, Science Daily/Massachusetts
General Hospital
 









Summary: Impulsive choice is exemplified
by choosing a small or poor reward that is available immediately,
in preference to a larger but delayed reward. Impulsive choice
contributes to drug addiction, attention-deficit/hyperactivity
disorder, mania, and personality disorders, but its
neuroanatomical basis is unclear. Here we show that selective
lesions of the nucleus accumbens core induce persistent impulsive
choice in rats. In contrast, damage to two of its afferents, the
anterior cingulate cortex and medial prefrontal cortex, had no
effect on this capacity. 



Impulsive
Choice Induced In Rats By Lesions Of The Nucleus
Accumbens Core,
Rudolf N. Cardinal, David R. Pennicott, C. Lakmali
Sugathapala, Trevor W. Robbins, Barry J. Everitt,
Science 292 (2001), 01/05/24, Science
10.1126/Science.1060818



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