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The Science of 	 Elections, Science
 









Abstract: Potassium channels that are sensitive to
adenosine triphosphate (ATP) couple the intracellular metabolic
state to electrical activity at the plasma membrane. Yamada et al.
(p. 1543) show in a knockout study that these channels exert a
protective effect in the brain during hypoxia. Mice lacking
ATP-sensitive K+-channels were more sensitive to generalized
seizures. In slice experiments, neurons from knockout animals in
the substantia nigra pars reticulata, an important brain area for
the control of seizures, began to depolarize upon a hypoxic
challenge rather than hyperpolarize like the neurons from normal
control animals. 



Metabolism,
Excitability, And
Seizures, Science,
Volume 292, Issue 5521, dated May 25 2001



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