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Complexity Digest 2005.49 - 03
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05/12/08

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Discovering Hidden Viral Piracy, Bioinformatics
 









Excerpts: Viruses and developers of anti-inflammatory therapies share a common
interest in proteins that manipulate the immune response. Large double-stranded
DNA viruses acquire host proteins to evade host defense mechanisms. Hence, viral
pirated proteins may have a therapeutic potential. Although dozens of viral
piracy events have already been identified, we hypothesized that sequence
divergence impedes the discovery of many others. We developed a method to assess
the number of viral/human homologs and discovered that at least 917 highly
diverged homologs are hidden in low-similarity alignment hits that are usually
ignored. (...)
Source: Discovering Hidden Viral Piracy[
http://bioinformatics.oxfordjournals.org/cgi/content/abstract/21/23/4216 ], E.
Kim, Y. Kliger - kligercompugen.co.il, DOI: 10.1093/bioinformatics/bti706,
Bioinformatics, Online 2005/10/06
Contributed by Pritha Das - prithadas01yahoo.com

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