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Complexity Digest 2007.38 - 11.01
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5-Oct-2007

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Taking Dendritic Cells Into Medicine, Nature
 









Excerpts: Dendritic cells (DCs) orchestrate a repertoire of immune responses
that bring about resistance to infection and silencing or tolerance to self. In
the settings of infection and cancer, microbes and tumours can exploit DCs to
evade immunity, but DCs also can generate resistance, a capacity that is readily
enhanced with DC-targeted vaccines. During allergy, autoimmunity and transplant
rejection, DCs instigate unwanted responses that cause disease, but, again, DCs
can be harnessed to silence these conditions with novel therapies. Here we
present some medical implications of DC biology that account for illness and
provide opportunities for prevention and therapy.
Source: Taking Dendritic Cells Into Medicine[
http://www.nature.com/nature/journal/v449/n7161/full/nature06175.html ], Ralph
M. Steinman, Jacques Banchereau, DOI: 10.1038/nature06175, Nature 449, 419-426,
07/09/27

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