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13-Mar-2008

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Signal Transduction: Sweet Conundrum, Science
 









Excerpts: High blood glucose concentration causes a transcription factor to be
modified with a sugar moiety, triggering the liver to produce yet more glucose.
(...) Simple substrates such as glucose and amino acids not only supply energy
for growth and biological functions, they also convey information, alerting the
organism to the nutritional state of the cellular environment. Thus, glucose not
only provides potential energy for generating adenosine 5¡¬-triphosphate in
unicellular organisms, but also instructs them to repress the synthesis of
enzymes that metabolize alternative substrates.
Source: Signal Transduction: Sweet Conundrum[
http://www.sciencemag.org/cgi/content/full/319/5868/1348 ], Morris J. Birnbaum,
Science : 1348-1349., 08/03/07

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