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14-Jan-2002

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CMOS Integrated	Circuit For Biosensor Applications, Biocybernetics and
Biomedical Engineering
 









Abstract: This paper presents a study on various CMOS
circuit and system design techniques for ISFET-based biosensor applications
including H+ sensing and hand-held pH meter implementation. Based on
constant-current and constant-voltage (CCCV) techniques, the conventional
floating gate and bridge-type floating source testing configurations for H+
sensing have been compared. Low voltage (1.5V/3V/5V) analog front-end readout
circuits for ISFET sensors and the succeeding dual-slope A/D converter have
been fabricated in a 0.5mm double-poly and double-metal CMOS technology. For
hand-held pH meter implementation, digital processing modules have been
realized by using on-chip digital control circuits and a single-chip 89C51
controller. The key functions of digital processing contain two-point
calibration, code converter and LCD display driver. Measurements have been
shown that low voltage CMOS circuits present acceptable performance including
linearity and flexibility for ISFET-based pH sensing system applications.





CMOS
Integrated Circuit And System Design For Ion-Sensitive FET-Based
Biosensor Applications, D. W. Y. Chung,
D. G. Pijanowska, W. Torbicz, P.-Ch. Wang, H.-S. Lin, J. Hsieh, G.-L.
Dong, M.-Y. You, Biocybernetics and Biomedical Engineering, Vol 21, No
4,2001

Contributed by Atin Das


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