@conference {GonzalezEtAl2001, title = {Integration of Computational Techniques for the Modelling of Signal Transduction}, booktitle = {Advances in Systems Science: Measurement, Circuits and Control}, year = {2001}, publisher = {WSES Press}, organization = {WSES Press}, abstract = {A cell can be seen as an adaptive autonomous agent or as a society of adaptive autonomous agents, where each can exhibit a particular behaviour depending on its cognitive capabilities. We present an intracellular signalling model obtained by integrating several computational techniques into an agent-based paradigm. Cellulat, the model, takes into account two essential aspects of the intracellular signalling networks: cognitive capacities and a spatial organization. Exemplifying the functionality of the system by modelling the EGFR signalling pathway, we discuss the methodology as well as the purposes of an intracellular signalling virtual laboratory, presently under development.}, url = {http://uk.arxiv.org/abs/cs.MA/0211030}, author = {P. P. Gonz{\'a}lez and M. C{\'a}rdenas and C. Gershenson and J. Lagunez}, editor = {N.E. Mastorakis and L.A. Pecorelli-Peres} } @conference {GonzalezEtAl2000b, title = {Modelling Intracellular Signalling Networks Using Behaviour-Based Systems and the Blackboard Architecture}, booktitle = {Proceedings of the International Conference: Mathematics and Computers in Biology and Chemistry {(MCBC} 2000)}, year = {2000}, address = {Montego Bay, Jamaica}, abstract = {This paper proposes to model the intracellular signalling networks using a fusion of behaviour-based systems and the blackboard architecture. In virtue of this fusion, the model developed by us, which has been named Cellulat, allows to take account two essential aspects of the intracellular signalling networks: (1) the cognitive capabilities of certain types of networks{\textquoteright} components and (2) the high level of spatial organization of these networks. A simple example of modelling of Ca2+ signalling pathways using Cellulat is presented here. An intracellular signalling virtual laboratory is being developed from Cellulat.}, url = {http://uk.arxiv.org/abs/cs.MA/0211029}, author = {P. P. Gonz{\'a}lez and C. Gershenson and M. C{\'a}rdenas and J. Lagunez} }