TY - CONF T1 - Integration of Computational Techniques for the Modelling of Signal Transduction T2 - Advances in Systems Science: Measurement, Circuits and Control Y1 - 2001 A1 - P. P. González A1 - M. Cárdenas A1 - C. Gershenson A1 - J. Lagunez ED - N.E. Mastorakis ED - L.A. Pecorelli-Peres AB - A cell can be seen as an adaptive autonomous agent or as a society of adaptive autonomous agents, where each can exhibit a particular behaviour depending on its cognitive capabilities. We present an intracellular signalling model obtained by integrating several computational techniques into an agent-based paradigm. Cellulat, the model, takes into account two essential aspects of the intracellular signalling networks: cognitive capacities and a spatial organization. Exemplifying the functionality of the system by modelling the EGFR signalling pathway, we discuss the methodology as well as the purposes of an intracellular signalling virtual laboratory, presently under development. JF - Advances in Systems Science: Measurement, Circuits and Control PB - WSES Press UR - http://uk.arxiv.org/abs/cs.MA/0211030 ER - TY - CONF T1 - Modelling Intracellular Signalling Networks Using Behaviour-Based Systems and the Blackboard Architecture T2 - Proceedings of the International Conference: Mathematics and Computers in Biology and Chemistry {(MCBC} 2000) Y1 - 2000 A1 - P. P. González A1 - C. Gershenson A1 - M. Cárdenas A1 - J. Lagunez AB - This paper proposes to model the intracellular signalling networks using a fusion of behaviour-based systems and the blackboard architecture. In virtue of this fusion, the model developed by us, which has been named Cellulat, allows to take account two essential aspects of the intracellular signalling networks: (1) the cognitive capabilities of certain types of networks' components and (2) the high level of spatial organization of these networks. A simple example of modelling of Ca2+ signalling pathways using Cellulat is presented here. An intracellular signalling virtual laboratory is being developed from Cellulat. JF - Proceedings of the International Conference: Mathematics and Computers in Biology and Chemistry {(MCBC} 2000) CY - Montego Bay, Jamaica UR - http://uk.arxiv.org/abs/cs.MA/0211029 ER -